Blood Cancer CAR-T Therapy Improved With Immune-Boosting Protein
A study recently released in Nature Communications has demonstrated improvement in CAR-T therapy for blood cancer when it’s paired with an immune-boosting protein. Researchers based the study on naturally produced protein, but improved effectiveness through genetic modification.
CAR-T Therapy Used for Treating Blood Cancer
CAR-T therapy is one of the most established treatments for certain blood cancers, but the treatment is far from perfect or always sufficiently effective. While it’s among the best treatments for these dangerous cancers, there still is significant room for improvement.
Researchers at large have been exploring potential ways to further increase CAR-T therapy’s effectiveness. This particular study is one of the most promising recent ones to be published.
Improving CAR-T Therapy With Immune-Boosing Protein
Improving therapy is what the researchers behind this study sought to do, and they drew inspiration from a naturally occurring protein. The protein they focused on was interleukin 7 (IL-7).
IL-7 is a naturally occurring protein that’s generated by the body. It has overall immune boosting effects, largely by increasing T cell production. In other words, the body uses IL-7 to create more T cells when fighting infection. Researchers hypothesized that CAR-T therapy would more effectively treat cancers if it were paired with IL-7.
Specifically, researchers thought that IL-7 might have exponential effects if paired with a genetically modified T-cell that has a longer duration than standard T cells. Standard T cells that the body produces disappear quickly. The modified T cells can circulate through the bloodstream for weeks, which could have a compounding effect if IL-7 proved useful.
The research was conducted on mice who had cancerous tumors, and the mice were grouped into three categories:
- Control mice that did not receive any active therapy, either CAR-T therapy or IL-7
- Mice that received genetically modified T cells without IL-7
- Mice that received genetically modified T cells paired with IL-7
Results Showed Substantial Improvement
The results showed a substantial improvement in the third group that received modified T cells and IL-7.
Mice that received CAR-T cell therapy but no IL-7 protein survived approximately one month longer than the control group. The tumor was temporarily controlled, shrinking for a brief time. The tumors in these mice returned around week 3, however, and the tumors appeared essentially the same as the control group’s tumors by week 4.
Mice that received CAR-T cell therapy and IL-7 protein survived almost six times longer than the CAR-T only group, not to mention the added life span was even greater if compared with the control group. All mice who received the joint treatment were still alive at 175 days. Their tumors were also dramatically reduced in size, and the reduction lasted throughout the experiment. Tumors in many of the mice were virtually undetectable after just over a month.
Promising for Clinical Treatment
The researchers noted that their study was promising, but more studies would be needed to determine exactly when and how much IL-7 protein should be given. These results are highly promising for patients who need CAR-T therapy because of blood cancer, though.
- How to grow your YouTube channel with email marketing August 24, 2023
- The Evolution of Tablets: Bridging the Digital Divide August 22, 2023
- The Role of Technology in Water Positivity: Innovations for Sustainable Water Solutions August 7, 2023
- Cold Heading in Parts Manufacturing July 25, 2023
- Effective Vendor Relationship Management July 25, 2023
- Eliminating Repetitive Tasks in Manufacturing July 25, 2023
- Four Home Repairs You Can Do on Your Own July 21, 2023
- August 2023
- July 2023
- June 2023
- May 2023
- April 2023
- March 2023
- February 2023
- December 2022
- November 2022
- October 2022
- August 2022
- July 2022
- June 2022
- May 2022
- April 2022
- February 2022
- January 2022
- December 2021
- November 2021
- October 2021
- September 2021
- August 2021
- July 2021
- June 2021
- May 2021
- April 2021
- March 2021
- February 2021
- January 2021
- December 2020
- November 2020
- October 2020
- August 2020
- July 2020
- June 2020
- May 2020
- April 2020
- March 2020
- February 2020
- January 2020
- May 2018